December 2015

Product Showcase

The Multifaceted Diode Array Detector and High-performance time-of-flight mass spectrometer for GC.high-performance time-of-flight mass spectrometer for GC

Manuscript Master Class

Getting your work published in a high-quality, peer-reviewed journal isn’t easy. But if you follow these 40 tips, you could at least avoid common errors that frustrate reviewers.

Going Further Together

Sitting Down With… Deirdre Cabooter, Assistant Professor, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium, and HTC-14 committee member.

Exploring the Economics of Innovation

Continual advances in liquid chromatography have raised the bar from high performance to ultra-high performance, resulting in increased analytical, instrument, and laboratory efficiency. What’s holding you back from investments in UHPLC technology?

Exploring Chirality in Outer Space

What is the origin of stereochemical bias – terrestrial autocatalytic processes, extraterrestrial contamination or otherworldly intervention? Here, I review the gas chromatographic tools being used in the search for homochirality in space – the final front

Raising the Bar for Routine Analysis

The Pesticide Explorer Collection comprises four complete workflows that meet the challenges of modern pesticide residue analysis. High-resolution, accurate mass measurements – courtesy of Orbitrap™ technology – represent the ultimate solutions for laboratories that want to take routine analysis to the next level.

Protecting Our Most Precious Resource: Water

New analytical capability can have a significant impact on research direction. In environmental analysis, high-resolution accurate mass (HRAM) mass spectrometry is allowing us to explore uncharted aspects of our increasingly complex chemical world.

To Attograms and Beyond

Every year sees new chemicals added to the list of analytes that may need to be measured in a given sample. At the same time, environmental levels of many older pollutants may be in decline – but still must be measured. How can analytical technology adapt

The Pros and Cons of Direct Injection

In water analysis, direct injection of samples into your LC-MS/MS system (without sample preparation beyond filtration) is possible because of advances in instrumentation. However, matrix effects must be monitored carefully – and sometimes may even prove u

What is pH?

This short and seemingly simple question belies the complexity of measuring – and interpreting – pH.

When No Standard is the Gold Standard

Can multi-angle light scattering aid in the characterization of proteins and antibody drug conjugates?

Teaching Computers Plasma Physics

The analytical performance of laser-induced breakdown spectroscopy (LIBS) can be improved dramatically by using an artificial neural network approach, opening up new opportunities for its application.

Celebrating Innovation – and 25 Years of SPME and GC×GC

Two important innovations in analytical science have reached their 25th anniversaries: solid phase micro-extraction (SPME) and comprehensive two-dimensional gas chromatography (GC×GC). Here’s why I think they are worth applauding.

Spot the Rot

Could carbon nanotubes hold the key to real-time, portable testing for meat freshness?

Exporting Analytics

GSK and the RSC embark on a five-year partnership to bring GC-MS skills to Africa

The Forensic Acid Test

Criminals “sweating it out” beware: a new amino acid test can tell male from female fingerprints

Keeping Up with the Dopers

A new LC-MS/MS screening method simultaneously detects a wide range of non-banned potentially performance enhancing drugs and masking agents in urine

Laptop Lab

Could NASA’s “chemical laptop” breathe new life into the search for extraterrestrials?

We’ve Only Just Begun...

We’ve Only Just Begun...

Evaluating the rheological properties of hyaluronic acid hydrogels for dermal filler applications

Polyol-induced increases in thermal stability of antibodies by DSC

Learn how differential scanning calorimetry can be used to assess the effects of polyol excipients on antibodies. DSC was used to monitor polyol-induced increases in thermal stability across seven monoclonal antibodies. The increases in thermal stability were measured as a function of polyol concentration and orientation of hydroxyl groups. It was found that increases in thermal stability were linear with respect to alcohol concentration.

Application of microcalorimetry in drug discovery at Exelixis

In this report, we illustrate the utility of calorimetry in making better laboratory decisions. Examples will include improved protein construct selection for scale-up; direct measurement of the effects of mutations and post-translational modifications on protein stability; rapid optimization of solvent formulation; direct measurement of substrate and inhibitor binding affinity; determination of the mode of inhibitor binding; characterization of protein-protein interactions; and improved structural biology efficiency, when used in conjunction of other biophysical methods.

Return of the TASIAs

Accurate measurement drives progress in science in immeasurable ways. Here, we celebrate a year’s worth of advances in The Analytical Scientist Innovation Awards 2014. What impact will these 15 TASIA winners have on your field?