Joseph Loo

Meet Joseph Loo

Eureka moment: My eureka moment came at the beginning of my career. I was trained to “break” molecules for analysis, so when developing ESI-MS for protein characterization it seemed natural to me to attempt to “break” the large protein molecules to sequence the fragments. After realizing I could generate gas-phase protein fragments and interpret the fragments against expected sequences, I saw that this could be further developed. Today we call this top-down MS, or proteomics… Little did I know I’d still be working on the same topic nearly 30 years later.